abstract：:Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between b...

journal_title：Genes

authors： Armendáriz-Castillo I,López-Cortés A,García-Cárdenas J,Guevara-Ramírez P,Leone PE,Pérez-Villa A,Yumiceba V,Zambrano AK,Guerrero S,Paz-Y-Miño C

更新日期：2020-07-21 00:00:00

abstract：:Polyspermia is an adverse phenomenon during mammalian fertilization when more than one sperm fuses with a single oocyte. The egg cell is prepared to prevent polyspermia by, among other ways, producing cortical granules (CGs), which are specialized intracellular structures containing enzymes that aim to harden the zona...

journal_title：Genes

authors： Kulus M,Kranc W,Jeseta M,Sujka-Kordowska P,Konwerska A,Ciesiółka S,Celichowski P,Moncrieff L,Kocherova I,Józkowiak M,Kulus J,Wieczorkiewicz M,Piotrowska-Kempisty H,Skowroński MT,Bukowska D,Machatkova M,Hanulakova S,Mozd

更新日期：2020-07-17 00:00:00

abstract：:White Spot Syndrome Virus (WSSV) is one of the main threats to farming Litopenaeus vannamei, the most important crustacean commercialized in aquaculture worldwide. Here, we performed RNA-seq analyses in hepatopancreas and muscle from WSSV-negative (healthy) and WSSV-positive (unhealthy) L. vannamei, previously exposed...

journal_title：Genes

authors： Santos CA,Andrade SCS,Fernandes JMO,Freitas PD

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Anthocyanin pigmentation characterizes a number of tissues of Citrus and its relatives. The gain and loss of pigmentation is intriguing and is inherited variously among species. METHODS:Citrus germplasm was used to investigate the anthocyanin pigmentation of tissues never before considered, including stamen...

journal_title：Genes

authors： Catalano C,Ciacciulli A,Salonia F,Russo MP,Caruso P,Caruso M,Russo G,Distefano G,Licciardello C

更新日期：2020-07-16 00:00:00

abstract：:Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...

journal_title：Genes

authors： Panasiak L,Dobosz S,Ocalewicz K

更新日期：2020-07-13 00:00:00

abstract：:Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...

journal_title：Genes

authors： Liu J,Bisseling T

更新日期：2020-07-11 00:00:00

abstract：:Diploid Alnus glutinosa s. str. and autotetraploid A. rohlenae form a narrow hybrid zone in a study area in southern Serbia, which results in triploid hybrid formation. The vast majority of previous studies have been focused on studies of maternal plants, but the offspring resulting from their crossing have not been m...

journal_title：Genes

authors： Šmíd J,Douda J,Krak K,Mandák B

更新日期：2020-07-09 00:00:00

abstract：:Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...

journal_title：Genes

authors： Pizzorusso T,Tognini P

更新日期：2020-07-03 00:00:00

abstract：:Croatian viticulture was most extensive at the beginning of the 20th century, when about 400 varieties were in use. Autochthonous varieties are the result of spontaneous hybridization from the pre-phylloxera era and are still cultivated today on about 35 % of vineyard area, while some exist only in repositories. We pr...

journal_title：Genes

authors： Žulj Mihaljević M,Maletić E,Preiner D,Zdunić G,Bubola M,Zyprian E,Pejić I

更新日期：2020-07-02 00:00:00

abstract：:The development of the udder and the milk yield are closely related to the number and vitality of mammary epithelial cells. Many previous studies have proved that non-coding RNAs (ncRNAs) are widely involved in mammary gland development and the physiological activities of lactation. Our laboratory previous sequencing ...

journal_title：Genes

authors： Zhang M,Ma L,Liu Y,He Y,Li G,An X,Cao B

更新日期：2020-06-28 00:00:00

abstract：:Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...

journal_title：Genes

authors： Fusco N,Sajjadi E,Venetis K,Gaudioso G,Lopez G,Corti C,Rocco EG,Criscitiello C,Malapelle U,Invernizzi M

更新日期：2020-06-28 00:00:00

abstract：:The study of DNA to predict externally visible characteristics (EVCs) and the biogeographical ancestry (BGA) from unknown samples is gaining relevance in forensic genetics. Technical developments in Massively Parallel Sequencing (MPS) enable the simultaneous analysis of hundreds of DNA markers, which improves successf...

journal_title：Genes

authors： Palencia-Madrid L,Xavier C,de la Puente M,Hohoff C,Phillips C,Kayser M,Parson W

更新日期：2020-06-26 00:00:00

abstract：:Background: Congenital disorder of glycosylation (CDG) is a severe morphogenic and metabolic disorder that affects all of the systems of organs and is caused by a mutation of the gene PMM2, having a mortality rate of 20% during the first months of life. Results: Here we report the outcome of an in vitro fertilisation ...

journal_title：Genes

authors： Doroftei B,Nemtanu L,Ilie OD,Simionescu G,Ivanov I,Anton E,Puiu M,Maftei R

更新日期：2020-06-25 00:00:00

abstract：:Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...

journal_title：Genes

authors： Castro Aviles A,Alan Harrison S,Joseph Arceneaux K,Brown-Guidera G,Esten Mason R,Baisakh N

更新日期：2020-06-25 00:00:00

abstract：:Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...

journal_title：Genes

authors： Tunjić Cvitanić M,Vojvoda Zeljko T,Pasantes JJ,García-Souto D,Gržan T,Despot-Slade E,Plohl M,Šatović E

更新日期：2020-06-24 00:00:00

abstract：:Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

journal_title：Genes

authors： Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

更新日期：2020-06-24 00:00:00

abstract：:Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals ...

journal_title：Genes

authors： Voß K,Tetens J,Thaller G,Becker D

更新日期：2020-06-22 00:00:00

abstract：:Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in the treatment of patients with severe impairment...

journal_title：Genes

authors： Filippenkov IB,Stavchansky VV,Denisova AE,Yuzhakov VV,Sevan'kaeva LE,Sudarkina OY,Dmitrieva VG,Gubsky LV,Myasoedov NF,Limborska SA,Dergunova LV

更新日期：2020-06-22 00:00:00

abstract：:There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...

journal_title：Genes

authors： Wee SK,Sivalingam SP,Yap EPH

更新日期：2020-06-18 00:00:00

abstract：:Satellite DNAs are tandemly repeated sequences preferentially assembled into large arrays within constitutive heterochromatin and their transcription is often activated by stress conditions, particularly by heat stress. Bioinformatic analyses of sequenced genomes however reveal single repeats or short arrays of satell...

journal_title：Genes

authors： Feliciello I,Sermek A,Pezer Ž,Matulić M,Ugarković Đ

更新日期：2020-06-18 00:00:00

abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...

journal_title：Genes

authors： Hu Y,Fragkostefanakis S,Schleiff E,Simm S

更新日期：2020-06-16 00:00:00

abstract：:Altered melanosome transport in melanocytes, resulting from variants in the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution in many species. In dogs, the MLPH gene corresponds to the D locus and two variants, c.-22G > A (d1) and c.705G > C (d2), leading to the dilution of coat colo...

journal_title：Genes

authors： Van Buren SL,Minor KM,Grahn RA,Mickelson JR,Grahn JC,Malvick J,Colangelo JR,Mueller E,Kuehnlein P,Kehl A

更新日期：2020-06-10 00:00:00

abstract：:This study investigated the effects of dietary terrestrial animal and plant proteins on the intestinal transcriptomes of yellowtail kingfish (YTK), Seriola lalandi, an ecologically and economically important marine species in Australia. Five diets containing fish meal (FM), poultry by-product meal (PBM), blood meal (B...

journal_title：Genes

authors： Dam CTM,Ventura T,Booth M,Pirozzi I,Salini M,Smullen R,Elizur A

更新日期：2020-06-05 00:00:00

abstract：:Novel coat colour phenotypes often emerge during domestication, and there is strong evidence of genetic selection for the two main genes that control base coat colour in horses-ASIP and MC1R. These genes direct the type of pigment produced, red pheomelanin (MC1R) or black eumelanin (ASIP), as well as the relative conc...

journal_title：Genes

authors： Corbin LJ,Pope J,Sanson J,Antczak DF,Miller D,Sadeghi R,Brooks SA

更新日期：2020-05-30 00:00:00

abstract：:Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...

journal_title：Genes

authors： Pewan SB,Otto JR,Huerlimann R,Budd AM,Mwangi FW,Edmunds RC,Holman BWB,Henry MLE,Kinobe RT,Adegboye OA,Malau-Aduli AEO

更新日期：2020-05-25 00:00:00

abstract：:DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomeras...

journal_title：Genes

authors： Hazeslip L,Zafar MK,Chauhan MZ,Byrd AK

更新日期：2020-05-21 00:00:00

abstract：:Recent advances in next-generation sequencing technology have led to the production of an unprecedented volume of genomic data, thus further advancing our understanding of the role of genetic variation in clinical pharmacogenomics. In the present study, we used whole exome sequencing data from 50,726 participants, as ...

journal_title：Genes

authors： Pandi MT,Williams MS,van der Spek P,Koromina M,Patrinos GP

更新日期：2020-05-18 00:00:00

abstract：:Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (AMPD1) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine ...

journal_title：Genes

authors： Leońska-Duniec A,Maculewicz E,Humińska-Lisowska K,Maciejewska-Skrendo A,Leźnicka K,Cięszczyk P,Sawczuk M,Trybek G,Wilk M,Lepionka W,Ficek K

更新日期：2020-05-16 00:00:00

abstract：:Single-cell RNA-seq (scRNA-seq) is quite prevalent in studying transcriptomes, but it suffers from excessive zeros, some of which are true, but others are false. False zeros, which can be seen as missing data, obstruct the downstream analysis of single-cell RNA-seq data. How to distinguish true zeros from false ones i...

journal_title：Genes

authors： Chi W,Deng M

更新日期：2020-05-11 00:00:00

abstract：:Transcriptional regulation of the genome arguably provides the basis for the anatomical elaboration and dynamic operation of the human brain. It logically follows that genetic variations affecting gene transcription contribute to mental health disorders, including autism spectrum disorder (ASD). A number of recent stu...

journal_title：Genes

authors： Kim Y,An JY

更新日期：2020-05-11 00:00:00

abstract：:In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...

journal_title：Genes

authors： Sürün D,Schneider A,Mircetic J,Neumann K,Lansing F,Paszkowski-Rogacz M,Hänchen V,Lee-Kirsch MA,Buchholz F

更新日期：2020-05-06 00:00:00

abstract：:Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...

journal_title：Genes

authors： Moon CI,Tompkins W,Wang Y,Godec A,Zhang X,Pipkorn P,Miller CA,Dehner C,Dahiya S,Hirbe AC

更新日期：2020-05-01 00:00:00

abstract：:The pseudostratified olfactory epithelium (OE) may histologically appear relatively simple, but the cytological relations among its cell types, especially those between olfactory receptor neurons (ORNs) and olfactory sustentacular cells (OSCs), prove more complex and variable than previously believed. Adding to the co...

journal_title：Genes

authors： Liang F

更新日期：2020-04-30 00:00:00

abstract：:Mobile DNA elements play a significant evolutionary role by promoting genome plasticity. Insertion sequences are the smallest prokaryotic transposable elements. They are highly diverse elements, and the ability to accurately identify, annotate, and infer the full genomic impact of insertion sequences is lacking. Halan...

journal_title：Genes

authors： Sadler M,R Mormile M,L Frank R

更新日期：2020-04-29 00:00:00

abstract：:Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...

journal_title：Genes

authors： M'kacher R,Colicchio B,Borie C,Junker S,Marquet V,Heidingsfelder L,Soehnlen K,Najar W,Hempel WM,Oudrhiri N,Wilhelm-Murer N,Miguet M,Arnoux M,Ferrapie C,Kerbrat W,Plesch A,Dieterlen A,Girinsky T,Voisin P,Deschenes G

更新日期：2020-04-27 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods that detect transgenes have been developed, many of them focus only on a sin...

journal_title：Genes

authors： Tozaki T,Ohnuma A,Kikuchi M,Ishige T,Kakoi H,Hirota KI,Kusano K,Nagata SI

更新日期：2020-04-23 00:00:00

abstract：:As a highly nutritious crop, Tartary buckwheat (Fagopyrum tartaricum) strongly adapts and grows in adverse environments and is widely grown in Asia. However, its flour contains a large proportion of the hull that adheres to the testa layer of the groats and is difficult to be removed in industrial processing. Fortunat...

journal_title：Genes

authors： Zhang L,Ma M,Liu L

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high preval...

journal_title：Genes

authors： Martin MJ,Estravís M,García-Sánchez A,Dávila I,Isidoro-García M,Sanz C

更新日期：2020-04-18 00:00:00

abstract：:Cell size affects almost all biosynthetic processes by controlling the size of organelles and disrupting the nutrient uptake process. Yeast cells must reach a critical size to be able to enter a new cell cycle stage. Abnormal changes in cell size are often observed under pathological conditions such as cancer disease....

journal_title：Genes

authors： Zhao X,Li X,Zhang P,Li C,Feng W,Zhu X,Wei D

更新日期：2020-04-16 00:00:00